ABSTRACT
Background: With the global epidemic of sepsis on the rising trend and gram negative sepsis being one of the most commoncause of increasing morbidity and mortality in developing nations like India, it becomes imperative to understand the role ofcombination antibiotics in controlling this burden. Aim and Methodology: In this study, we recognized the potential therapeuticrole of Meropenem combined with EDTA against a clinical endemic isolate of multi-drug resistant extended spectrum betalactamases (ESBLs) producing pathogens was investigated. The E-test strips studied the antimicrobial susceptibility of thepathogens and were applied to check for in-vitro sensitivity to Meropenem and combination of Meropenem and Ca-EDTA. Result:The MIC value of Meropenem-EDTA (0.25) was less than 50% of that of Meropenem (2.45) in sensitive isolates. Conclusion:Meropenem in unification with EDTA can exhibit more potent antimicrobial activity against ESBL producing pathogens thanjust Meropenem or EDTA alone.